prophylactic probiotics for prevention of necrotizing enterocolitis (nec) in low birth weight neonates
نویسندگان
چکیده
background probiotics are thought to interfere with the mechanisms involving in the pathogenesis of necrotizing enterocolitis in neonates. objectives this study was planned to assess the effect of prophylactic probiotics for the prevention of necrotizing enterocolitis in low birth weight neonates. patients and methods this prospective triple-blinded, interventional, randomized clinical trial enrolled 136 low birth weight newborn infants with a minimum birth weight of 700 g, from september 2010 to september 2011. the study and control groups were compared regarding; 1- occurrence of nec, 2- time to reach full feeding, defined as days required to reach full enteral feeding, 3- duration of hospital course, and 4-incidence of sepsis and death. the study group was fed with milk and protexin (restore) and the control group was fed with milk and a placebo that was physically indistinguishable from the probiotic powder. spss version 16 was used, and p-value less than 0.05 was considered significant. results one hundred thirty six neonates were enrolled in the study. seventy six (54.4%) were male. the mean of gestational age and birth weight were 31 weeks and 1407 grams, respectively. the mean age to start feeding was 4.36 days. there was not any significant difference in the nec cases between the two groups. conclusions this study did not show any benefit from prophylactic probiotics in the prevention of necrotizing enterocolitis in low birth weight neonates which could be probably due to low dose probiotics used.
منابع مشابه
prophylactic probiotics for prevention of necrotizing enterocolitis (nec) in low birth weight neonates; quality of the evidence
متن کامل
Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns.
Our study showed that enteral administration of prophylactic probiotics in neonatal intensive care setup could significantly reduce morbidity due to necrotising enterocolitis in very low birth weight newborn. It also helps in establishing early full enteral feeding and reduces hospital stay.
متن کاملOral probiotics prevent necrotizing enterocolitis in very low birth weight neonates.
OBJECTIVE To test the hypothesis that normalizing the intestinal flora by administration of prophylactic probiotics would provide a natural defense, thereby reducing both the incidence and severity of necrotizing enterocolitis (NEC) in preterm neonates. STUDY DESIGN Neonates < or =1500 g birth weight were randomized to either receive a daily feeding supplementation with a probiotic mixture (B...
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متن کاملProbiotics for the prevention of necrotizing enterocolitis.
Necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality for low birth weight premature infants. Prematurity, ischemia, formula feeding, and bacterial colonization are risk factors for the self-perpetuating cycle of damaged intestinal epithelia, inflammation, bacterial entry, sepsis, and shock that characterizes NEC. Probiotics are food supplements containing live ...
متن کاملProbiotics and the prevention of necrotizing enterocolitis.
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عنوان ژورنال:
archives of pediatric infectious diseasesجلد ۲، شماره ۱، صفحات ۱۷۴-۱۷۹
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